2 edition of Synthesis of fluorinated BINOL ligands and asymmetric catalysis with derived catalysts. found in the catalog.
Synthesis of fluorinated BINOL ligands and asymmetric catalysis with derived catalysts.
Written in English
|Contributions||University of Toronto. Dept. of Chemistry.|
|The Physical Object|
|Number of Pages||76|
ligands for the development of asymmetric catalysts for carbonyla-tion tandem reactions and development of sensitizers based on tetrapyrrolic macrocycles for biomedicinal applications and envir-onmental catalysis. She has published ca. peer-reviewed papers in international journals, 2 books, and 4 book chapters and is the inventor of 2 patents. Towards perfect asymmetric catalysis: When binol‐derived N‐spiro quaternary ammonium salts were used as phase‐transfer catalysts in the conjugate addition of nitroalkanes to chalcones and its analogues, an intriguing reversal of enantioselectivity was observed. Novel chiral catalysts have been designed and synthesized (see structure).
For example, new catalysts can selectively lower the activation barrier of C−F and C−CF 3 bond formation in aromatic fluorination and trifluoromethylation, respectively, and new chiral. Williams, Neil and Merzouk, Mahboub () Synthesis and evaluation of (imino-alkyl)imidazolylidene ligands in asymmetric catalysis. In: 5th International Symposium on Transition Metals in Organic Synthesis; September , Glasgow, Scotland. (Unpublished) Full text .
Combining Asymmetric Catalysis with Natural Product Functionalization through Enantioselective r-Fluorination gically relevant R-fluorinated carbonyl derivatives of select chemotherapeutics, antibiotics, and other pharma- derivatization have both made powerful contributions to organic synthesis and practical drug discovery alike.1 In File Size: KB. The Synthesis of Chiral Phosphorus Ligands for use in Homogeneous Metal Catalysis Dr. Susan Lühr Leibniz‐Institut für Katalyse an der Universität Rostock e. V. A. Einstein‐Str. 29a, Rostock (Germany), Fax: (+49) ‐
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Thesis Title: Synthesis of fluorinated BINOL ligands and asymmetnc catalysis with its derived catalysts. Degree: Master of Science Year of Convocation: 1 Name of Student: Gang Chen Department: Department of Chemistry Universiîy: UniversiSr of Toronto Abstract: The effect of fluorine substitution at the 5, Y, 6,6', 7,7', 8 and 8' positions ofCited by: 1.
The design and synthesis of chiral ligands has played an important role in the development of transition metal-catalysed asymmetric reactions.1 In general, metal-complexes of the effective chiral phosphine ligands are 5, 6 or 7-membered rings.
While a big bite angle (P–M–P) has a special effect in asymmetric catalysis.2 It is difficult to. Modified BINOL Ligands in Asymmetric Catalysis His main research interests are in the areas of asymmetric synthesis and catalysis.
Shahla Yekta was born in Tehran, Iran, in Addition and Correction to Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Cited by: of Knowles, Noyori, and Sharpless in the development of catalytic asymmetric synthesis, highlighting the importance of chiral synthesis in chemistry.
The pioneering work of Noyori in the s with BINAP ligands began an era where catalysts and ligands became more effective and selective. Chiral ferrocene ligands have been widely used in asymmetric catalysis. The advantages of using ferrocene as a scaffold for chiral ligands are described, particularly those regarding planar.
Several aspects of chiral P-ligands, such as theoretical background, synthesis, application, coordination chemistry, and asymmetric catalysis, have been reviewed during the past The design and application of linked-BINOLs investigated in our group are reviewed.
Linked-BINOLs are a kind of semi-crown ether, thus they are flexible and applicable to metals having various ionic radii (Ga 3+, Li +, Zn 2+, In 3+, La 3+, and Y 3+).The flexible linker segment, containing a coordinative heteroatom, has a crucial role in the construction of a unique and effective chiral Cited by: The fruitful development of transition metal catalysed asymmetric transformations over the last decades has been largely steered by the introduction of new chiral ligands.
1 Bidentate C 2-symmetric diphosphines are a prominent ligand class and structures such as DuPHOS and BINAP belong to the most efficient chiral ligands for many different metal-catalysed reactions.
2 In contrast, only a Cited by: 9. Modified BINOL ligands in asymmetric catalysis. Chen Y(1), Yekta S, Yudin AK. Author information: (1)Department of Chemistry, University of Toronto, Davenport Building, 80 St.
George Street, Toronto, Ontario, M5S 3H6 Canada. PMID: Cited by: The synthesis of new C 2-symmetric chiral ligands consisting of two binaphthol units linked by a short bridge is ligands can be used for investigating catalytic asymmetric reactions which utilize BINOL or related ligands as was demonstrated for the ring opening reaction of cyclohexene oxide with by: The catalytic asymmetric epoxidation of enones using the La−BINOL−Ph3AsO complex generated from La(O-i-Pr)3, BINOL, and Ph3AsO in a ratio of is described herein.
Using 1−5 mol % of the asymmetric catalyst, a variety of enones, including a dienone and a cis-enone, were found to be epoxidized in a reasonable reaction time, providing the corresponding epoxy ketones in up to 99%.
BINOL-Derived Diphosphoramidites bearing Unsymmetrical 1,2-Diamine Link and their Application in Asymmetric Catalysis. Fluorinated Alcohols as Solvents for Enantioselective Hydrogenation with Chiral Self-Assembling Rh-Catalysts.
Phosphorus Ligands in Asymmetric Catalysis - Synthesis and Application, A. Börner, Hrsg.; Wiley-VCH. First published on 25th October All domains of chemistry are increasingly impacted by organofluorine molecules, often favorably. In asymmetric synthesis of fluorinated compounds, significant achievements are the result of extensive research efforts toward appropriate experimental conditions rather than of the rationalization of fluorine by: Catalysts and Ligands for Enantioselective Au CatalysisWang et al.
modes of activation for asymmetric gold catalysis that did not involve addition of a prochiral nucleophile to a gold-activated alkyne. To this end, we were inspired by observa-tions made during the course of our investigation of gold. Given the excellent regioselectivity provided by phosphite ligands, we wished to explore chiral variants of these and electronically similar phosphoramidite ligands to effect the [4+2] cycloaddition enantioselectively.
34 Although we 13a and others 11 had previously reported BINOL-derived mononuclear phosphoramiditegold(I) complexes, reactions Cited by: Asymmetric Catalysis of the Strecker Amino Acid Synthesis by a Cyclic DipeptideCited by: Although the use of BINOL-derived phosphoric acids has been known for over 40 years in organic synthesis, their usage as catalysts started only 10 years ago.
Akiyama is widely credited as one of the pioneers of the field with his report in on the chiral Brønsted acid-catalyzed Mannich by: suitable asymmetric catalysts still poses one of the most challenging endeavours of contemporary chemistry.
The research described in this thesis aimed to develop a new class of privileged chiral ligands for asymmetric catalysis, by functionalization of natural molecules such as carbohydrates.
Detlef Selent. The olefin hydroformylation reaction (synthesis of carbaldehydes by addition of carbon monoxide and hydrogen to an olefin) ranks among the most important technically applied reactions performed using homogeneous transition metal catalysts.
Depending on the catalyst applied, either terminal aldehydes or isoaldehydes can be formed, which to a large extend are used as. Discovery of new chiral phosphorus ligands plays a critical role in asymmetric catalysis.1 Atropisomeric 1,1-binaphthalene core is the parent framework of steadily increasing families of chiral ligands for asymmetric reactions.2 Reetz3 and Pringle4 prepared chelating chiral phosphites using readily accessible Binaphthol (BINOL).
A library of new fine-tunable monodentate phosphite and phosphoramidite ligands based on chiral biphenol has been designed and developed. These monodentate phosphorus ligands have exhibited excellent enantioselectivity in the Pd-catalyzed asymmetric allylic alkylation, Rh-catalyzed asymmetric hydrogenation and hydroformylation, and Cu-catalyzed conjugate addition by: 5.Recent studies in asymmetric catalysis using ferrocenyl ligands q IUPAC, Pure Appl.
Chem. 71, – Scheme 4 Synthesis of new ‘inversed’ P,N- and N,N-ligands. Scheme 5 Different allyl conﬁguration of major diastereoisomeric intermediate lead to product of same conﬁguration.Covers homogeneous asymmetric hydrogenation, asymmetric catalysis via chiral metal complexes, heterogeneous catalysis and non-organometallic catalysis.
The collection of a range of stereoselective reactions illustrate various strategies and methodologies as well as their general by: